Neuroparticle™ therapy promises non-invasive means of delivering deep brain stimulation treatment for addiction and neurological disease.


   
  
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     Magnetic particle transport in mouse brain.  Particles transported across midline with magnetic gradients. 

Magnetic particle transport in mouse brain. Particles transported across midline with magnetic gradients. 

Deep-brain stimulation has been used to successfully treat alcohol addiction.

Reference:

J. Kuhn, M. Möller, J. F. Treppmann, C. Bartsch, D. Lenartz, T. O. J. Gruendler, M. Maarouf, A. Brosig, U. B. Barnikol, J. Klosterkötter, and V. Sturm, “Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction,” Mol. Psychiatry, vol. 19, no. 2, pp. 145–146, Feb. 2014.

Nasally-administered neuroparticles bypass the blood-brain barrier in mice.

Reference:

I. Weinberg, A. Nacev, A. Sarwar, O. Rodriguez, C. Albanese, B. Shapiro, P. Stepanov, D. Beylin, M. Urdaneta, R. Probst, and S. Fricke, “Non-Invasive Image-Guided Brain Access with Gradient Propulsion of Magnetic Nanoparticles,” in Proceedings of the IEEE Medical Imaging Meeting, 2012. DOI: 10.1109/NSSMIC.2012.6551857.

Neuroparticles can activated neurons with externally-applied magnetic fields

Reference:

A. Nacev, I. N. Weinberg, L. O. Mair, R. Hilaman, S. Jafari, C. DaSilva, J. Baker-McKee, and S. Chowdhury, “Neurostimulation using mechanical motion of magnetic particles wiggled by external oscillating magnetic gradients,” A Nacev, Weinberg, LO Mair, R Hilaman, J Algarin, Proc. Eighth Int. IEEE EMBS Neural Eng. Conf. Shanghai 2017. DOI: 10.1109/NER.2017.8008380.”