Neuroparticle™ therapy promises non-invasive means of delivering deep brain stimulation treatment for addiction and neurological disease.
Deep-brain stimulation has been used to successfully treat alcohol addiction.
J. Kuhn, M. Möller, J. F. Treppmann, C. Bartsch, D. Lenartz, T. O. J. Gruendler, M. Maarouf, A. Brosig, U. B. Barnikol, J. Klosterkötter, and V. Sturm, “Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction,” Mol. Psychiatry, vol. 19, no. 2, pp. 145–146, Feb. 2014.
Nasally-administered neuroparticles bypass the blood-brain barrier in mice.
I. Weinberg, A. Nacev, A. Sarwar, O. Rodriguez, C. Albanese, B. Shapiro, P. Stepanov, D. Beylin, M. Urdaneta, R. Probst, and S. Fricke, “Non-Invasive Image-Guided Brain Access with Gradient Propulsion of Magnetic Nanoparticles,” in Proceedings of the IEEE Medical Imaging Meeting, 2012. DOI: 10.1109/NSSMIC.2012.6551857.
Neuroparticles can activated neurons with externally-applied magnetic fields
A. Nacev, I. N. Weinberg, L. O. Mair, R. Hilaman, S. Jafari, C. DaSilva, J. Baker-McKee, and S. Chowdhury, “Neurostimulation using mechanical motion of magnetic particles wiggled by external oscillating magnetic gradients,” A Nacev, Weinberg, LO Mair, R Hilaman, J Algarin, Proc. Eighth Int. IEEE EMBS Neural Eng. Conf. Shanghai 2017. DOI: 10.1109/NER.2017.8008380.”